Esra Mutlu, Ph.D., is a chemist in the Chemistry and ADME (absorption, distribution, metabolism and excretion) Resources Group in the Program Operations Branch (POB) in the Division of the National Toxicology Program (NTP). Mutlu provides NTP with expertise in organic chemistry, analytical chemistry, and interpretation and application of mass spectrometry and serves on NTP study design teams to provide technical assistance in these areas of chemistry.
As a chemist, Mutlu is involved in the design, conduct, interpretation and reporting of NTP research and testing activities that investigate the toxicology of a variety of chemicals and complex mixtures including botanicals, polycyclic aromatic hydrocarbons, sunscreen ingredients, and phenolic benzotriazoles. Mutlu’s research interests include using state-of-the-art mass spectrometric techniques to quantitate products of reactive metabolites of xenobiotics with DNA and other macromolecules. She is also interested in understanding the mode of action of chemicals and their metabolites in vivo.
Mutlu received her BSc (Honors) in Chemistry from Yildiz Technical University, Istanbul, Turkey in 2001 and her Ph.D. in Organic Chemistry from University of Newcastle upon Tyne, UK in 2004. She joined University of North Carolina at Chapel Hill as a Goldberg postdoctoral fellow in Curriculum of Toxicology, where she developed assays to quantitate DNA adducts of xenobiotics and/or their metabolites by mass spectrometric techniques which were applied to samples from in vivo and in vitro exposures. In 2011, she joined the U.S. Environmental Protection Agency as a postdoctoral fellow and was actively involved in research on chemistry, mutagenicity and mutagenic emission factors of particulate matters of diesel, biodiesel, and wood stove emissions. She worked as a research associate at University of North Carolina Gillings School of Global Public Health briefly prior to joining NTP in 2014 as a chemist.